TargetMol

(+)-JQ-1

Product Code:
 
TAR-T2110
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2110-5mg5mg£116.00
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TAR-T2110-10mg10mg£130.00
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TAR-T2110-25mg25mg£148.00
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Quantity:
TAR-T2110-50mg50mg£189.00
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This product comes from: United States.
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Further Information

Bioactivity:
(+)-JQ1 is a BET bromodomain inhibitor (IC50: 77 nM/33 nM for BRD4 (1/2)).
CAS:
1268524-70-4
Formula:
C23H25ClN4O2S
Molecular Weight:
456.99
Pathway:
Autophagy; Chromatin/Epigenetic
Purity:
0.9997
SMILES:
Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n-21)c1ccc(Cl)cc1
Target:
Epigenetic Reader Domain; Autophagy

References

1. Filippakopoulos P, et al. Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468(7327):1067-73. 2. Delmore JE, et al. BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell. 2011 Sep 16;146(6):904-17. 3. Matzuk MM, et al. Small-molecule inhibition of BRDT for male contraception. Cell. 2012 Aug 17;150(4):673-84. 4. Mertz JA, et al. Targeting MYC dependence in cancer by inhibiting BET bromodomains. Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16669-74. 5. Wang M, Zhao L, Tong D, et al. BET bromodomain inhibitor JQ1 promotes immunogenic cell death in tongue squamous cell carcinoma[J]. International Immunopharmacology. 2019, 76: 105921.