TargetMol

I-BET151

Product Code:
 
TAR-T2120
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2120-1mg1mg£103.00
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TAR-T2120-2mg2mg£118.00
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TAR-T2120-5mg5mg£148.00
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TAR-T2120-1mL1 mL * 10 mM (in DMSO)£156.00
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TAR-T2120-10mg10mg£164.00
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TAR-T2120-25mg25mg£242.00
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TAR-T2120-50mg50mg£357.00
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TAR-T2120-100mg100mg£499.00
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Quantity:
TAR-T2120-500mg500mg£1,026.00
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Further Information

Bioactivity:
I-BET151 (GSK1210151A) is a specific BET inhibitor for BRD2/3/4 (IC50: 0.5/0.25/0.79 μM, in cell-free assays).
CAS:
1300031-49-5
Formula:
C23H21N5O3
Molecular Weight:
415.453
Pathway:
Chromatin/Epigenetic
Purity:
0.9963
SMILES:
COc1cc2c3n([C@H](C)c4ccccn4)c(=O)[nH]c3cnc2cc1-c1c(C)noc1C
Target:
Epigenetic Reader Domain

References

1. Dawson MA, et al. Nature, 2011, 478(7370), 529-533. 2. Xiong C, Deng J, Wang X, et al. Pharmacologic Targeting of BET Proteins Attenuates Hyperuricemic Nephropathy in Rats[J]. Frontiers in Pharmacology. 2021, 12: 147. 3. Maksylewicz A, Bysiek A. BET bromodomain inhibitors suppress inflammatory activation of gingival fibroblasts and epithelial cells from periodontitis patients[J]. Frontiers in Immunology. 2019 Apr 30;10:933.