TargetMol

NSC 66811

Product Code:
 
TAR-T21578
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T21578-1mg1mg£95.00
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TAR-T21578-2mg2mg£103.00
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TAR-T21578-5mg5mg£122.00
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TAR-T21578-1mL1 mL * 10 mM (in DMSO)£127.00
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TAR-T21578-10mg10mg£145.00
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TAR-T21578-25mg25mg£193.00
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TAR-T21578-50mg50mg£254.00
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TAR-T21578-100mg100mg£345.00
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TAR-T21578-200mg200mg£470.00
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Further Information

Bioactivity:
NSC 66811is a novel inhibitor of the murine double minute 2 (MDM2)-p53 interaction. It binds to MDM2 with a Ki of 120 nM and activates p53 in cancer cells with a mechanism of action consistent with targeting the MDM2-p53 interaction.
CAS:
6964-62-1
Formula:
C23H20N2O
Molecular Weight:
340.426
Pathway:
Apoptosis
Purity:
0.9694
SMILES:
Cc1ccc2ccc(C(Nc3ccccc3)c3ccccc3)c(O)c2n1
Target:
Mdm2

References

1. Yipin Lu, et al. Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy. J Med Chem. 2006 Jun 29;49(13):3759-62.