TargetMol

TWS119

Product Code:
 
TAR-T2166
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2166-5mg5mg£105.00
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TAR-T2166-1mL1 mL * 10 mM (in DMSO)£108.00
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TAR-T2166-10mg10mg£127.00
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TAR-T2166-25mg25mg£181.00
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TAR-T2166-50mg50mg£274.00
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Quantity:
TAR-T2166-100mg100mg£422.00
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This product comes from: United States.
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Further Information

Bioactivity:
TWS119 is a GSK-3β inhibitor; capable of inducing neuronal differentiation
CAS:
601514-19-6
Formula:
C18H14N4O2
Molecular Weight:
318.336
Pathway:
Autophagy; PI3K/Akt/mTOR signaling; Stem Cells
Purity:
0.9814
SMILES:
Nc1cccc(c1)-c1cc2c(Oc3cccc(O)c3)ncnc2[nH]1
Target:
GSK-3; Autophagy

References

1. Ding S, et al, Pro Natl Acad Sci U S A, 2003, 100(13), 7632-7637. 2. Ding S, et al, Nat Biotechnol, 2004, 22(7), 833-840. 3. Kordes C, et al, Biochem Biophys Res Commun, 2008, 367(1), 116-123. 4. Gattinoni L, et al, Nat Mediicine, 2009, 15(7), 808-813. 5. Muralidharan S, et al, J Immunol, 2011, 187(10), 5521-5532. 6. Wang W, et al. GSK-3? inhibitor TWS119 attenuates rtPA-induced hemorrhagic transformation and activates the Wnt/?-catenin signaling pathway after acute ischemic stroke in rats. Mol Neurobiol. 2016 Dec;53(10):7028-7036. Epub 2015 Dec 15. 7. Chen YQ, et al. Wnt pathway activator TWS119 enhances the proliferation and cytolytic activity of human ??T cells against colon cancer. Exp Cell Res. 2017 Nov 16. pii: S0014-4827(17)30587-6.