TargetMol

A-286982

Product Code:
 
TAR-T21781
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T21781-1mg1mg£95.00
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TAR-T21781-2mg2mg£105.00
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TAR-T21781-5mg5mg£125.00
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TAR-T21781-1mL1 mL * 10 mM (in DMSO)£130.00
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TAR-T21781-10mg10mg£158.00
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TAR-T21781-25mg25mg£249.00
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Quantity:
TAR-T21781-50mg50mg£367.00
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Quantity:
TAR-T21781-100mg100mg£511.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
A 286982 is an inhibitor that blocks the integrin-ligand interaction between leukocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-1.
CAS:
280749-17-9
Formula:
C24H27N3O4S
Molecular Weight:
453.56
Pathway:
Cytoskeletal Signaling
Purity:
0.9724
SMILES:
CC(C)c1ccccc1Sc1ccc(C=CC(=O)N2CCN(CC2)C(C)=O)cc1[N+]([O-])=O
Target:
Integrin

References

1. Liu G, Link JT, Pei Z, et al. Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. Identification of an additional binding pocket based on an anilino diaryl sulfide lead. J Med Chem. 2000;43(21):4025-4040. doi:10.1021/jm0002782 2. Keating SM, Clark KR, Stefanich LD, et al. Competition between intercellular adhesion molecule-1 and a small-molecule antagonist for a common binding site on the alphal subunit of lymphocyte function-associated antigen-1. Protein Sci. 2006;15(2):290-303. doi:10.1110/ps.051583406