TargetMol

Pregnenolone Carbonitrile

Product Code:
 
TAR-T21818
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T21818-2mg2mg£102.00
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TAR-T21818-5mg5mg£122.00
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TAR-T21818-1mL1 mL * 10 mM (in DMSO)£127.00
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TAR-T21818-10mg10mg£148.00
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TAR-T21818-25mg25mg£206.00
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TAR-T21818-50mg50mg£270.00
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TAR-T21818-100mg100mg£370.00
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Further Information

Bioactivity:
Pregnenolone Carbonitrile is an activator of rodent-PXR and induces the expression of CYP3A.
CAS:
1434-54-4
Formula:
C22H31NO2
Molecular Weight:
341.49
Pathway:
Metabolism
Purity:
0.98
SMILES:
C[C@@]12[C@]([C@]3([C@](CC1)([C@]4(C)C(=CC3)C[C@@H](O)CC4)[H])[H])(C[C@@H](C#N)[C@@H]2C(C)=O)[H]
Target:
P45

References

1. Carylyn J Marek, et al. Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms. Biochem J. 2005 May 1;387(Pt 3):601-8. 2. Yang Xie, et al. Activation of Pregnane X Receptor Sensitizes Mice to Hemorrhagic Shock-Induced Liver Injury. Hepatology. 2019 Sep;70(3):995-1010. 3. Simon Lowes, et al. The Effects of Pregnenolone 16?-Carbonitrile Dosing on Digoxin Pharmacokinetics and Intestinal Absorption in the Rat. Pharmaceutics. 2010 Mar 15;2(1):61-77. 4. Jeffrey Guzelian, et al. Identification of genes controlled by the pregnane X receptor by microarray analysis of mRNAs from pregnenolone 16alpha-carbonitrile-treated rats. Toxicol Sci. 2006 Dec;94(2):379-87.