TargetMol

Proteasome inhibitor IX

Product Code:
 
TAR-T21854
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T21854-2mg2mg£96.00
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TAR-T21854-5mg5mg£111.00
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TAR-T21854-1mL1 mL * 10 mM (in DMSO)£132.00
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TAR-T21854-10mg10mg£135.00
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TAR-T21854-25mg25mg£201.00
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TAR-T21854-50mg50mg£301.00
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TAR-T21854-100mg100mg£454.00
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TAR-T21854-200mg200mg£623.00
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TAR-T21854-500mg500mg£914.00
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Further Information

Bioactivity:
AM 114 is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 ~1 μM). AM 114 shows potent anticancer activity. AM 114 exhibits HCT116 p53+/+ cells growth inhibitory activity(IC50 = 1.49 μM).
CAS:
856849-35-9
Formula:
C20H21B2NO5
Molecular Weight:
377.01
Pathway:
Ubiquitination; Proteases/Proteasome
Purity:
0.987
SMILES:
O=C(/C(CN(C)C/1)=CC2=CC=C(B(O)O)C=C2)C1=C/C3=CC=C(B(O)O)C=C3
Target:
Proteasome

References

1. Encouse B Golden, et al. Green Tea Polyphenols Block the Anticancer Effects of Bortezomib and Other Boronic Acid-Based Proteasome Inhibitors. Blood. 2009 Jun 4;113(23):5927-37. 2. Geetha Achanta , et al. A Boronic-Chalcone Derivative Exhibits Potent Anticancer Activity Through Inhibition of the Proteasome. Mol Pharmacol. 2006 Jul;70(1):426-33.