TargetMol

MDR-652

Product Code:
 
TAR-T22360
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T22360-1mg1mg£124.00
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TAR-T22360-2mg2mg£149.00
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TAR-T22360-5mg5mg£201.00
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TAR-T22360-1mL1 mL * 10 mM (in DMSO)£213.00
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TAR-T22360-10mg10mg£269.00
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TAR-T22360-25mg25mg£429.00
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TAR-T22360-50mg50mg£611.00
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TAR-T22360-100mg100mg£840.00
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Further Information

Bioactivity:
MDR-652 is a highly specific and efficacious agonist of nonpungent transient receptor potential vanilloid 1 (TRPV1) with Ki value of 11.4 nM and 23.8 nM for hTRPV1 and rTRPV1 respectively and EC50s for hTRPV1 and rTRPV1 are 5.05 and 93 nM respectively. MDR-652 is a potent topical analgesic.
CAS:
1933528-96-1
Formula:
C22H23ClFN3O2S
Molecular Weight:
447.95
Pathway:
Membrane transporter/Ion channel
Purity:
0.9996
SMILES:
CC(C)(C)c1nc(-c2cccc(Cl)c2)c(CNC(Nc2cc(F)c(CO)cc2)=O)s1
Target:
TRP/TRPV Channel

References

1. Jihyae Ann, et al. Discovery of Nonpungent Transient Receptor Potential Vanilloid 1 (TRPV1) Agonist as Strong Topical Analgesic. J Med Chem. 2020 Jan 9;63(1):418-424.