TargetMol

ICG001

Product Code:
 
TAR-T2237
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2237-1mg1mg£100.00
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TAR-T2237-2mg2mg£111.00
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TAR-T2237-5mg5mg£128.00
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TAR-T2237-1mL1 mL * 10 mM (in DMSO)£176.00
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TAR-T2237-10mg10mg£176.00
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TAR-T2237-25mg25mg£302.00
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Quantity:
TAR-T2237-50mg50mg£394.00
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TAR-T2237-100mg100mg£543.00
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Quantity:
TAR-T2237-500mg500mg£1,099.00
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Further Information

Bioactivity:
ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CREB)-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300.
CAS:
847591-62-2
Formula:
C33H32N4O4
Molecular Weight:
548.63
Pathway:
Chromatin/Epigenetic; Stem Cells; Cytoskeletal Signaling
Purity:
0.9863
SMILES:
Oc1ccc(C[C@@H]2N3[C@H](CN(Cc4cccc5ccccc45)C2=O)N(CCC3=O)C(=O)NCc2ccccc2)cc1
Target:
Epigenetic Reader Domain; Wnt/beta-catenin

References

1. Sasaki T, et al. Transl Respir Med. 2:8. 2. Zhang X, et al. Am J Cancer Res. 2015, 5(8):2344-2360. 3. Yosuke Osawa, et al. EBioMedicine. 2015, 2(11):1751-1758. 4. Liu F, Yu F, Lu Y Z, et al. Crosstalk between pleural mesothelial cell and lung fibroblast contributes to pulmonary fibrosis[J]. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 2020, 1867(11): 118806.