TargetMol

PF-6274484

Product Code:
 
TAR-T22396
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T22396-2mg2mg£98.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T22396-5mg5mg£115.00
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Quantity:
TAR-T22396-1mL1 mL * 10 mM (in DMSO)£119.00
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Quantity:
TAR-T22396-10mg10mg£145.00
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Quantity:
TAR-T22396-25mg25mg£229.00
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Quantity:
TAR-T22396-50mg50mg£367.00
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Quantity:
TAR-T22396-100mg100mg£511.00
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Quantity:
TAR-T22396-500mg500mg£1,026.00
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Quantity:
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* Rare exceptions are clearly labelled (only 0.14% of items!).
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
PF 6274484, a high affinity, irreversible covalent inhibitor of EGFR kinase with Ki of 0.14 nM, inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells with IC50 of 5.8 nM and 6.6 nM, respectively.
CAS:
1035638-91-5
Formula:
C18H14ClFN4O2
Molecular Weight:
372.78
Pathway:
Tyrosine Kinase/Adaptors; JAK/STAT signaling; Angiogenesis
Purity:
0.9912
SMILES:
COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)C=C
Target:
EGFR