TargetMol

Serdemetan

Product Code:
 
TAR-T2243
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2243-2mg2mg£102.00
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TAR-T2243-5mg5mg£122.00
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TAR-T2243-1mL1 mL * 10 mM (in DMSO)£127.00
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TAR-T2243-10mg10mg£148.00
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TAR-T2243-25mg25mg£230.00
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TAR-T2243-50mg50mg£369.00
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TAR-T2243-100mg100mg£517.00
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TAR-T2243-500mg500mg£1,050.00
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This product comes from: United States.
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Further Information

Bioactivity:
Serdemetan is an orally bioavailable HDM2 antagonist with potential antineoplastic activity.
CAS:
881202-45-5
Formula:
C21H20N4
Molecular Weight:
328.419
Pathway:
Ubiquitination; Apoptosis
Purity:
0.98
SMILES:
C(Cc1c[nH]c2ccccc12)Nc1ccc(Nc2ccncc2)cc1
Target:
Apoptosis; Mdm2; E1/E2/E3 Enzyme; p53

References

1. Kojima K, et al. Mol Cancer Ther. 2010, 9(9), 2545-2557. 2. Yuan Y, et al. J Hematol Oncol. 2011, 4:16. 3. Chargari C, et al. Cancer Lett. 2011, 312(2), 209-218. 4. Smith MA, et al. Pediatr Blood Cancer, 2012, 59(2), 329-332. 5. Liu Z, Chen Y, Gao H, et al. Berberine Inhibits Cell Proliferation by Interfering with Wild-Type and Mutant P53 in Human Glioma Cells[J]. OncoTargets and Therapy . 2020, 13: 12151-12162.