TargetMol

Bretazenil

Product Code:
 
TAR-T22616
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T22616-1mg1mg£109.00
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TAR-T22616-2mg2mg£129.00
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TAR-T22616-5mg5mg£160.00
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TAR-T22616-1mL1 mL * 10 mM (in DMSO)£165.00
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TAR-T22616-10mg10mg£217.00
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TAR-T22616-25mg25mg£390.00
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TAR-T22616-50mg50mg£546.00
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TAR-T22616-100mg100mg£749.00
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This product comes from: United States.
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Further Information

Bioactivity:
Bretazenil is a GABAA benzodiazepine site partial agonist. Bretazenil shows an EC50 of 10 nM for recombinant α1β1γ2.
CAS:
84379-13-5
Formula:
C19H20BrN3O3
Molecular Weight:
418.28
Pathway:
Neuroscience; Membrane transporter/Ion channel
Purity:
0.98
SMILES:
BrC1=C2C(N3[C@H](C4=C(C(OC(C)(C)C)=O)N=CN4C2=CC=C1)CCC3)=O
Target:
GABA Receptor

References

1. Puia G, et al. Molecular mechanisms of the partial allosteric modulatory effects of bretazenil at gamma-aminobutyric acid type A receptor. Proc Natl Acad Sci U S A. 1992;89(8):3620-3624. 2. Kubov? H, et al. Anticonvulsant effects of bretazenil (Ro 16-6028) during ontogenesis. Epilepsia. 1993;34(6):1130-1134. 3. Finn DA, et al. A comparison of Ro 16-6028 with benzodiazepine receptor 'full agonists' on GABAA receptor function. Eur J Pharmacol. 1993;247(3):233-237.