TargetMol

CHM-1

Product Code:
 
TAR-T22661
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
❮❯

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CodeSizePrice
TAR-T22661-1mg1mg£115.00
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TAR-T22661-2mg2mg£136.00
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TAR-T22661-5mg5mg£177.00
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TAR-T22661-10mg10mg£249.00
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TAR-T22661-25mg25mg£454.00
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TAR-T22661-50mg50mg£621.00
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TAR-T22661-100mg100mg£871.00
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Quantity:
TAR-T22661-500mg500mg£1,669.00
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This product comes from: United States.
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Further Information

Bioactivity:
CHM-1 is an inducer of apoptosis, and displays potent antitumor ability in human hepatocellular carcinoma by activation of Cdc2 kinase activity. CHM-1 inhibits tubulin polymerization in vitro and in vivo.
CAS:
154554-41-3
Formula:
C16H10FNO3
Molecular Weight:
283.258
Pathway:
Apoptosis; Cytoskeletal Signaling;
Purity:
0.98
SMILES:
Fc1ccccc1-c1cc(=O)c2cc3OCOc3cc2[nH]1
Target:
Apoptosis; Microtubule Associated

References

1. Liu CW, et al. CHM-1, a novel microtubule-destabilizing agent exhibits antitumor activity via inducing the expression of SIRT2 in human breast cancer cells. Chem Biol Interact. 2018 Jun 1;289:98-108. 2. Tsai AC, et al. CHM-1, a new vascular targeting agent, induces apoptosis of human umbilical vein endothelial cells via p53-mediated death receptor 5 up-regulation. J Biol Chem. 2010 Feb 19;285(8):5497-506. 3. Wang SW, et al. CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo. Mol Cancer Ther. 2008 Feb;7(2):350-60.