TargetMol

MIRA-1

Product Code:
 
TAR-T22980
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T22980-2mg2mg£98.00
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TAR-T22980-5mg5mg£115.00
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TAR-T22980-1mL1 mL * 10 mM (in DMSO)£119.00
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TAR-T22980-10mg10mg£148.00
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TAR-T22980-25mg25mg£229.00
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TAR-T22980-50mg50mg£309.00
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TAR-T22980-100mg100mg£431.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
MIRA-1 is a restorer of wild-type p53 conformation/cellular function and selectively inhibits Werner syndrome WRN helicase activity with an IC50 of 20 ?M.
CAS:
72835-26-8
Formula:
C8H9NO4
Molecular Weight:
183.163
Pathway:
Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Apoptosis
Purity:
0.98
SMILES:
CCC(=O)OCN1C(=O)C=CC1=O
Target:
DNA/RNA Synthesis; p53

References

1. Moles R, Bai XT, Chaib-Mezrag H, Nicot C. WRN-targeted therapy using inhibitors NSC 19630 and NSC 617145 induce apoptosis in HTLV-1-transformed adult T-cell leukemia cells. J Hematol Oncol. 2016 Nov 9;9(1):121. 2. Bou-Hanna C, Jarry A, Lode L, Schmitz I, Schulze-Osthoff K, Kury S, Bezieau S, Mosnier JF, Laboisse CL. Acute cytotoxicity of MIRA-1/NSC19630, a mutant p53-reactivating small molecule, against human normal and cancer cells via a caspase-9-dependent apoptosis. Cancer Lett. 2015 Apr 10;359(2):211-7.