TargetMol

SB-505124

Product Code:
 
TAR-T2462
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2462-1mg1mg£98.00
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TAR-T2462-2mg2mg£109.00
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TAR-T2462-5mg5mg£136.00
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TAR-T2462-10mg10mg£174.00
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TAR-T2462-1mL1 mL * 10 mM (in DMSO)£185.00
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TAR-T2462-25mg25mg£258.00
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Quantity:
TAR-T2462-50mg50mg£386.00
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TAR-T2462-100mg100mg£533.00
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Quantity:
TAR-T2462-500mg500mg£1,050.00
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This product comes from: United States.
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Further Information

Bioactivity:
SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5.
CAS:
694433-59-5
Formula:
C20H21N3O2
Molecular Weight:
335.407
Pathway:
Angiogenesis; Tyrosine Kinase/Adaptors; Stem Cells
Purity:
0.9992
SMILES:
Cc1cccc(n1)-c1[nH]c(nc1-c1ccc2OCOc2c1)C(C)(C)C
Target:
ALK; TGF-beta/Smad

References

1. DaCosta Byfield S, et al. Mol Pharmacol. 2004, 65(3), 744-752. 2. Hu T, et al. Am J Physiol Renal Physiol. 2005, 289(4), F816-825. 3. Misumi S, et al. Eur J Neurosci. 2008, 28(6), 1049-1059. 4. Goto N, et al. Cancer Sci. 2011, 102(8), 1501-1508. 5. Sapitro J, et al. Mol Vis. 2010 ,16, 1880-1892. 6. Marini KD, et al. Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy. Sci Transl Med. 2018 Jul 25;10(451). pii: eaat3504. 7. Kalli M, Mpekris F, Wong C K, et al. Activin A signaling regulates IL13R?2 expression to promote breast cancer metastasis[J]. Frontiers in oncology. 2019 Feb 5;9:32.