TargetMol

Osu03012

Product Code:
 
TAR-T2466
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
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CodeSizePrice
TAR-T2466-2mg2mg£95.00
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Quantity:
TAR-T2466-1mL1 mL * 10 mM (in DMSO)£108.00
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TAR-T2466-5mg5mg£108.00
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TAR-T2466-10mg10mg£134.00
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TAR-T2466-25mg25mg£188.00
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Quantity:
TAR-T2466-50mg50mg£293.00
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Quantity:
TAR-T2466-200mg200mg£454.00
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Quantity:
TAR-T2466-100mg100mg£470.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
AR-12 is an orally bioavailable, small-molecule, celecoxib-derived inhibitor of phosphoinositide-dependent kinase-1 (PDK1) with potential antineoplastic activity.
CAS:
742112-33-0
Formula:
C26H19F3N4O
Molecular Weight:
460.46
Pathway:
PI3K/Akt/mTOR signaling
Purity:
0.9922
SMILES:
NCC(=O)Nc1ccc(cc1)-n1nc(cc1-c1ccc2c(ccc3ccccc23)c1)C(F)(F)F
Target:
PDK

References

1. Zhu J, et al. Cancer Res, 2004, 64(12), 4309-4318. 2. Yacoub A, et al. Mol Pharmacol, 2006, 70(2), 589-603. 3. Porchia LM, et al. Mol Pharmacol, 2007, 72(5), 1124-1131. 4. Gao M, et al. Cancer Res, 2008, 68(22), 9348-9357. 5. Tseng PH, et al. Blood, 2005, 105(10), 4021-4027. 6. Zhang Yajuan, et al. Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis[J]. Molecular cell. 2018 Jul 19;71(2):201-215.e7.