TargetMol

BI-69A11

Product Code:
 
TAR-T25150
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T25150-1mg1mg£101.00
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TAR-T25150-2mg2mg£112.00
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TAR-T25150-5mg5mg£131.00
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TAR-T25150-1mL1 mL * 10 mM (in DMSO)£146.00
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TAR-T25150-10mg10mg£148.00
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TAR-T25150-25mg25mg£222.00
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TAR-T25150-50mg50mg£289.00
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TAR-T25150-100mg100mg£383.00
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Further Information

Bioactivity:
BI-69A11 is a dual AKT and NFkB pathway inhibitor. It enhances the susceptibility of colon cancer cells to mda-7/IL-24-induced growth inhibition by targeting Akt.
CAS:
1233322-09-2
Formula:
C25H16ClN3O2
Molecular Weight:
425.87
Pathway:
NF-κb; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
Purity:
0.98
SMILES:
Oc1nc2ccc(Cl)cc2c(-c2ccccc2)c1C(=O)C=Cc1nc2ccccc2[nH]1
Target:
NF-κB; Akt

References

1. Pal I, Sarkar S, et al. BI-69A11 enhances susceptibility of colon cancer cells to mda-7/IL-24-induced growth inhibition by targeting Akt. Br J Cancer. 2014 Jul 8;111(1):101-11. 2. Pal I, Parida S, et al. Blockade of autophagy enhances proapoptotic potential of BI-69A11, a novel Akt inhibitor, in colon carcinoma. Eur J Pharmacol. 2015 Oct 15;765:217-27. 3. Feng Y, Lau E, et al. Inhibition of melanoma development in the Nras((Q61K)) ::Ink4a(-/-) mouse model by the small molecule BI-69A11. Pigment Cell Melanoma Res. 2013 Jan;26(1):136-42. 4. Pal I, Dey KK, Chaurasia M, Parida S, Das S, Rajesh Y, Sharma K, Chowdhury T, Mandal M. Cooperative effect of BI-69A11 and celecoxib enhances radiosensitization by modulating DNA damage repair in colon carcinoma. Tumour Biol. 2016 May;37(5):6389-402. doi: 10.1007/s13277-015-4399-6. Epub 2015 Dec 2. PubMed PMID: 26631035.