TargetMol

Lumacaftor

Product Code:
 
TAR-T2595
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2595-5mg5mg£105.00
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Quantity:
TAR-T2595-1mL1 mL * 10 mM (in DMSO)£109.00
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Quantity:
TAR-T2595-10mg10mg£119.00
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TAR-T2595-25mg25mg£131.00
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Quantity:
TAR-T2595-50mg50mg£149.00
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Quantity:
TAR-T2595-100mg100mg£171.00
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Quantity:
TAR-T2595-500mg500mg£322.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
VX-809 is a CFTR modulator that corrects the folding and trafficking of CFTR protein. It enhances F508del-CFTR protein maturation in FRT cells (EC50: 100 nM).
CAS:
936727-05-8
Formula:
C24H18F2N2O5
Molecular Weight:
452.414
Pathway:
Autophagy; Membrane transporter/Ion channel
Purity:
0.9972
SMILES:
Cc1ccc(NC(=O)C2(CC2)c2ccc3OC(F)(F)Oc3c2)nc1-c1cccc(c1)C(O)=O
Target:
CFTR; Autophagy

References

1. Van Goor F, et al. Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809. Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18843-8. 2. Phuan PW, et al. Synergy-based small-molecule screen using a human lung epithelial cell line yields ?F508-CFTR correctors that augment VX-809 maximal efficacy. Mol Pharmacol. 2014 Jul;86(1):42-51.