TargetMol

AZ13705339

Product Code:
 
TAR-T26704
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26704-2mg2mg£102.00
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Quantity:
TAR-T26704-5mg5mg£122.00
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TAR-T26704-10mg10mg£149.00
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TAR-T26704-25mg25mg£249.00
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TAR-T26704-50mg50mg£356.00
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Quantity:
TAR-T26704-100mg100mg£530.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
AZ13705339 is an effective inhibitor of PAK1 with an IC50 of 0.33 nM and a Kd of 0.28 nM. AZ13705339 binds PAK2 with a Kd of 0.32 nM. AZ13705339 can be used in studies about cancers.
CAS:
2016806-57-6
Formula:
C33H36FN7O3S
Molecular Weight:
629.75
Pathway:
Cytoskeletal Signaling
Purity:
0.9857
SMILES:
N#CC=1C=CC=CC1CN(C2=NC(=NC=C2F)NC3=CC=C(C(=C3)S(=O)(=O)CC)N4CCN(C)CC4)C5=CC(=CC=C5C)CO
Target:
PAK

References

1. McCoull W, et al. Optimization of Highly Kinase Selective Bis-anilino Pyrimidine PAK1 Inhibitors. ACS Med Chem Lett. 2016 Sep 14;7(12):1118-1123. eCollection 2016 Dec 8. 2. Daniela J Carroll, et al. Siglec-8 Signals Through a Non-Canonical Pathway to Cause Human Eosinophil Death In Vitro. Front Immunol. 2021 Oct 11;12:737988. 3. Martin F M de Rooij, et al. A loss-of-adhesion CRISPR-Cas9 screening platform to identify cell adhesion-regulatory proteins and signaling pathways. Nat Commun. 2022 Apr 19;13(1):2136.