TargetMol

KN-62

Product Code:
 
TAR-T2694
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2694-1mg1mg£95.00
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TAR-T2694-2mg2mg£106.00
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TAR-T2694-5mg5mg£125.00
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TAR-T2694-1mL1 mL * 10 mM (in DMSO)£161.00
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TAR-T2694-10mg10mg£161.00
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TAR-T2694-25mg25mg£254.00
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TAR-T2694-50mg50mg£430.00
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TAR-T2694-100mg100mg£599.00
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This product comes from: United States.
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Further Information

Bioactivity:
KN-62 is a potent and specific Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor with Ki of 0.9 μM.
CAS:
127191-97-3
Formula:
C38H35N5O6S2
Molecular Weight:
721.85
Pathway:
Neuroscience; Membrane transporter/Ion channel; Autophagy
Purity:
0.9877
SMILES:
CN([C@@H](Cc1ccc(OS(=O)(=O)c2cccc3cnccc23)cc1)C(=O)N1CCN(CC1)c1ccccc1)S(=O)(=O)c1cccc2cnccc12
Target:
CaMK; P2X Receptor; Autophagy

References

1. Tokumitsu H, et al. J Biol Chem. 1990, 265(8), 4315-4320. 2. Wenham RM, et al. Biochem Biophys Res Commun. 1992, 189(1), 128-133. 3. Minami H, et al. Biochem Biophys Res Commun. 1994, 199(1), 241-248. 4. Murray KD, et al. Eur J Neurosci. 1998, 10(1), 377-387. 5. Pellicena P, et al. Front Pharmacol. 2014, 20;5:21. 6. Manosso LM, et al. Antidepressant-like effect of zinc is dependent on signaling pathways implicated in BDNF modulation. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Jun 3;59:59-67.