TargetMol

FTI-277 hydrochloride

Product Code:
 
TAR-T2700
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2700-1mg1mg£109.00
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TAR-T2700-2mg2mg£124.00
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TAR-T2700-5mg5mg£148.00
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TAR-T2700-1mL1 mL * 10 mM (in DMSO)£161.00
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TAR-T2700-10mg10mg£219.00
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TAR-T2700-25mg25mg£341.00
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TAR-T2700-50mg50mg£524.00
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TAR-T2700-100mg100mg£707.00
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This product comes from: United States.
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Further Information

Bioactivity:
FTI 277 hydrochloride is an effective and specific farnesyltransferase (FTase) inhibitor (IC50: 500 pM); this selectivity is about 100-fold than the closely related GGTase I.
CAS:
180977-34-8
Formula:
C22H30ClN3O3S2
Molecular Weight:
484.07
Pathway:
Apoptosis; MAPK; GPCR/G Protein; Metabolism
Purity:
0.9819
SMILES:
Cl.COC(=O)[C@H](CCSC)NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c1ccccc1
Target:
Apoptosis; Transferase; Ras

References

1. Lerner EC, et al. J Biol Chem. 1995, 270(45), 26802-26806. 2. Bernhard EJ, et al. Cancer Res. 1996, 56(8), 1727-1730. 3. Bolick SC, et al. Leukemia. 2003, 17(2), 451-457 4. Pirompul N, et al. Neurosci Lett. 2013, 545, 138-143. 5. Bordier BB, et al. J Clin Invest. 2003, 112(3), 407-414. 6. Nakazawa H, et al. Role of protein farnesylation in burn-induced metabolic derangements and insulin resistance in mouse skeletal muscle. PLoS One. 2015 Jan 16;10(1):e0116633. 7. Sun Q, Xiong K, Yuan Y, et al. Inhibiting fungal echinocandin resistance by small-molecule disruption of geranylgeranyltransferase type I activity[J]. Antimicrobial Agents and Chemotherapy. 2020, 64(2).