TargetMol

Pifithrin- α hydrobromide

Product Code:
 
TAR-T2707
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2707-2mg2mg£97.00
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TAR-T2707-5mg5mg£112.00
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TAR-T2707-1mL1 mL * 10 mM (in DMSO)£114.00
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TAR-T2707-10mg10mg£136.00
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TAR-T2707-25mg25mg£215.00
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TAR-T2707-50mg50mg£306.00
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TAR-T2707-100mg100mg£422.00
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This product comes from: United States.
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Further Information

Bioactivity:
Pifithrin-α is a p53 inhibitor, inhibiting p53-dependent transactivation of p53-responsive genes.
CAS:
63208-82-2
Formula:
C16H19BrN2OS
Molecular Weight:
367.31
Pathway:
Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
Purity:
0.9854
SMILES:
Br.Cc1ccc(cc1)C(=O)Cn1c2CCCCc2sc1=N
Target:
Ferroptosis; Aryl Hydrocarbon Receptor; p53

References

1. Komarov PG, et al. Science, 1999, 285(5434), 1733-1737. 2. Culmsee C, et al. J Neurochem, 2001, 77(1), 220-228. 3. Komarova EA, et al. J Biol Chem, 2003, 278(18), 15465-15468. 4. Murphy PJ, et al. J Biol Chem, 2004, 279(29), 320195-3201201. 5. Leker RR, et al. Exp Neurol, 2004, 187(2), 478-486. 6. Yu W, et al. Cyclosporine A Suppressed Glucose Oxidase Induced P53 Mitochondrial Translocation and Hepatic Cell Apoptosis through Blocking Mitochondrial Permeability Transition. Int J Biol Sci. 2016 Jan 1;12(2):198-209. 7. Kuang SQ, et al. FOXE3 mutations predispose to thoracic aortic aneurysms and dissections. J Clin Invest. 2016 Mar 1;126(3):948-61. 8. Lu L, Li K, Mao Y H, et al. Gold-chrysophanol nanoparticles suppress human prostate cancer progression through inactivating AKT expression and inducing apoptosis and ROS generation in vitro and in vivo[J]. International journal of oncology. 2017 Oct;51(4):1089-1103. 9. Zhou Y, Yang L, Xiong L, et al. KIF11 is upregulated in colorectal cancer and silencing of it impairs tumor growth and sensitizes colorectal cancer cells to oxaliplatin via p53/GSK3? signaling[J]. Journal of Cancer. 2021, 12(12): 3741.