TargetMol

DCG04

Product Code:
 
TAR-T27131
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T27131-100mg100mgEnquire
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Further Information

Bioactivity:
DCG04 is a multivalent ligand for the mannose-6-phosphate receptor. DCG-04 is an activity-based probe for cysteine cathepsins, enabled fluorescent readout of its receptor-targeting properties. DCG04 is used for endolysosomal targeting of an activity-based probe.
CAS:
314263-42-8
Formula:
C43H66N8O11S
Molecular Weight:
903.11
Purity:
0.98
SMILES:
CCOC(=O)C1OC1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCC(=O)N[C@@H](CCCCNC(=O)CCCCC1SCC2NC(=O)NC12)C(N)=O

References

1. Hoogendoorn S, van Puijvelde GH, Kuiper J, van der Marel GA, Overkleeft HS. A multivalent ligand for the mannose-6-phosphate receptor for endolysosomal targeting of an activity-based probe. Angew Chem Int Ed Engl. 2014 Oct 6;53(41):10975-8. doi: 10.1002/anie.201406842. Epub 2014 Aug 27. PubMed PMID: 25163608. 2. Greenbaum D, Medzihradszky KF, Burlingame A, Bogyo M. Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools. Chem Biol. 2000 Aug;7(8):569-81. PubMed PMID: 11048948. 3. Hillaert U, Verdoes M, Florea BI, Saragliadis A, Habets KL, Kuiper J, Van Calenbergh S, Ossendorp F, van der Marel GA, Driessen C, Overkleeft HS. Receptor-mediated targeting of cathepsins in professional antigen presenting cells. Angew Chem Int Ed Engl. 2009;48(9):1629-32. doi: 10.1002/anie.200805529. Erratum in: Angew Chem Int Ed Engl. 2009;48(14):2442.. Saragliadis, Anastasios [corrected to Saragliadis, Athanasios]. PubMed PMID: 19156780. 4. Kasn? M, Mikes L, Dalton JP, Mountford AP, Hor?k P. Comparison of cysteine peptidase activities in Trichobilharzia regenti and Schistosoma mansoni cercariae. Parasitology. 2007 Oct;134(Pt 11):1599-609. Epub 2007 May 22. PubMed PMID: 17517170.