TargetMol

HBF-0259

Product Code:
 
TAR-T27527
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27527-1mg1mg£114.00
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TAR-T27527-2mg2mg£132.00
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TAR-T27527-5mg5mg£173.00
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TAR-T27527-1mL1 mL * 10 mM (in DMSO)£185.00
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TAR-T27527-10mg10mg£249.00
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TAR-T27527-25mg25mg£372.00
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TAR-T27527-50mg50mg£515.00
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TAR-T27527-100mg100mg£704.00
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TAR-T27527-500mg500mg£1,348.00
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Further Information

Bioactivity:
HBF-0259 is an inhibitors of hepatitis B virus surface antigen (HBsAg) secretion with an EC50 of 11.3 μM and a CC50 value of >50 μM in HepG2.2.15 cells. HBF-0259 had a EC50 of approximately 1.5 microM in a secondary, HBV-expressing cell line, with a concentration that exhibited 50% cytotoxicity of >50 microM. The equilibrium concentration of HBF-0259 in aqueous solution at physiological pH was 15 to 16 microM; the selective index was thus >9.
CAS:
957011-15-3
Formula:
C16H12Cl2FN5
Molecular Weight:
364.21
Pathway:
Immunology/Inflammation
Purity:
0.98
SMILES:
Fc1cccc(Cl)c1C1CC(Nc2nnnn12)c1ccc(Cl)cc1
Target:
Antiviral

References

1. Yu W, Goddard C, Clearfield E, Mills C, Xiao T, Guo H, Morrey JD, Motter NE, Zhao K, Block TM, Cuconati A, Xu X. Design, synthesis, and biological evaluation of triazolo-pyrimidine derivatives as novel inhibitors of hepatitis B virus surface antigen (HBsAg) secretion. J Med Chem. 2011 Aug 25;54(16):5660-70. doi: 10.1021/jm200696v. Epub 2011 Aug 2. PubMed PMID: 21786803; PubMed Central PMCID: PMC3158247. 2. Dougherty AM, Guo H, Westby G, Liu Y, Simsek E, Guo JT, Mehta A, Norton P, Gu B, Block T, Cuconati A. A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion. Antimicrob Agents Chemother. 2007 Dec;51(12):4427-37. Epub 2007 Sep 17. PubMed PMID: 17875990; PubMed Central PMCID: PMC2167973.