TargetMol

NGB 2904

Product Code:
 
TAR-T28167
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28167-1mg1mg£103.00
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TAR-T28167-2mg2mg£116.00
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TAR-T28167-5mg5mg£142.00
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TAR-T28167-1mL1 mL * 10 mM (in DMSO)£165.00
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TAR-T28167-10mg10mg£182.00
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TAR-T28167-25mg25mg£294.00
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TAR-T28167-50mg50mg£464.00
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TAR-T28167-100mg100mg£627.00
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TAR-T28167-500mg500mg£1,235.00
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Further Information

Bioactivity:
NGB2904 is a potent and selective antagonist of dopamine D3 receptor (Ki values are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D3, D2, 5-HT2, α1, D4, D1 and D5 receptors respectively). NGB2904 potently antagonizes mitogenesis stimulated by quinpirole (IC50 = 6.8 nM).
CAS:
189060-98-8
Formula:
C28H30Cl3N3O
Molecular Weight:
530.92
Pathway:
Neuroscience; GPCR/G Protein;
Purity:
0.9935
SMILES:
O=C(c(cc1)cc(C2)c1-c1c2cccc1)NCCCCN(CC1)CCN1c1cccc(Cl)c1Cl.Cl
Target:
Dopamine Receptor; 5-HT Receptor

References

1. Hussein N, Amawi H, Karthikeyan C, Hall FS, Mittal R, Trivedi P, Ashby CR Jr, Tiwari AK. The dopamine D(3) receptor antagonists PG01037, NGB2904, SB277011A, and U99194 reverse ABCG2 transporter-mediated drug resistance in cancer cell lines. Cancer Lett. 2017 Mar 18.