TargetMol

Isorhamnetin

Product Code:
 
TAR-T2836
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2836-1mg1mg£98.00
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TAR-T2836-5mg5mg£131.00
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TAR-T2836-1mL1 mL * 10 mM (in DMSO)£133.00
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TAR-T2836-10mg10mg£168.00
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TAR-T2836-25mg25mg£269.00
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TAR-T2836-50mg50mg£402.00
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TAR-T2836-100mg100mg£544.00
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TAR-T2836-500mg500mg£1,091.00
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Further Information

Bioactivity:
Isorhamnetin is the methylated metabolite of quercetin. Quercetin is an important dietary flavonoid with in vitro antioxidant activity. Isorhamnetin prevents endothelial cell injuries from oxidized LDL via inhibition of lectin-like ox-LDL receptor-1 upregulation, interference of ox-LDL-mediated intracellular signaling pathway (p38MAPK activation, NF-kappaB nuclear translocation, eNOS expression) and the antioxidant activity of isorhamnetin. Isorhamnetin prevents endothelial dysfunction, superoxide production, and overexpression of p47phox induced by angiotensin II. Isorhamnetin appears to be a potent drug against esophageal cancer due to it's in vitro potential to not only inhibit proliferation but also induce apoptosis of Eca-109 cells.
CAS:
480-19-3
Formula:
C16H12O7
Molecular Weight:
316.265
Pathway:
PI3K/Akt/mTOR signaling; Metabolism; MAPK
Purity:
0.9811
SMILES:
COc1cc(ccc1O)-c1oc2cc(O)cc(O)c2c(=O)c1O
Target:
MEK; PI3K; Endogenous Metabolite

References

1. Han X, et al. Biomol Ther (Seoul). 2015 Jul;23(4):357-66. 2. Kuang Y, Chai Y, Xu L, et al. Glabrone as a specific UGT1A9 probe substrate and its application in discovering the inhibitor glycycoumarin[J]. European Journal of Pharmaceutical Sciences. 2021: 105786.