TargetMol

VU0453595

Product Code:
 
TAR-T29137
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T29137-1mg1mg£106.00
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TAR-T29137-2mg2mg£121.00
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TAR-T29137-1mL1 mL * 10 mM (in DMSO)£148.00
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TAR-T29137-5mg5mg£148.00
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TAR-T29137-10mg10mg£201.00
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TAR-T29137-25mg25mg£326.00
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TAR-T29137-50mg50mg£466.00
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TAR-T29137-100mg100mg£648.00
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Further Information

Bioactivity:
VU0453595 is a M1 positive allosteric modulator (PAM).
CAS:
1432436-13-9
Formula:
C18H15FN4O
Molecular Weight:
322.343
Pathway:
Neuroscience
Purity:
0.98
SMILES:
Cn1cc(cn1)-c1ccc(CN2Cc3ncccc3C2=O)c(F)c1
Target:
AChR

References

1. Lv X, et al. M(1) muscarinic activation induces long-lasting increase in intrinsic excitability of striatal projection neurons. Neuropharmacology. 2017 May 15;118:209-222. 2. Panarese JD, et al. Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetration. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3822-5. 3. Ghoshal A, et al. Potentiation of M1 Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse Model. Neuropsychopharmacology. 2016 Jan;41(2):598-610.