TargetMol

Z944

Product Code:
 
TAR-T29201
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T29201-1mg1mg£109.00
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TAR-T29201-2mg2mg£124.00
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TAR-T29201-5mg5mg£161.00
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TAR-T29201-1mL1 mL * 10 mM (in DMSO)£221.00
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TAR-T29201-10mg10mg£222.00
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TAR-T29201-25mg25mg£409.00
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TAR-T29201-50mg50mg£575.00
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TAR-T29201-100mg100mg£788.00
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Further Information

Bioactivity:
Z944 is a T-type calcium channel blocker. Z944 delays the progression of seizures in the amygdala kindling model. Z944 disrupts prepulse inhibition in both epileptic and non-epileptic rats.
CAS:
1199236-64-0
Formula:
C19H27ClFN3O2
Molecular Weight:
383.89
Pathway:
Membrane transporter/Ion channel; Metabolism
Purity:
0.9829
SMILES:
CC(C)(C)NC(=O)CN1CCC(CNC(=O)c2cc(F)cc(Cl)c2)CC1
Target:
Calcium Channel

References

1. Marks WN, Greba Q, Cain SM, Snutch TP, Howland JG. The T-type calcium channel antagonist Z944 disrupts prepulse inhibition in both epileptic and non-epileptic rats. Neuroscience. 2016 Sep 22;332:121-9. doi: 10.1016/j.neuroscience.2016.06.035. PubMed PMID: 27365170. 2. Marks WN, Cain SM, Snutch TP, Howland JG. The T-type calcium channel antagonist Z944 rescues impairments in crossmodal and visual recognition memory in Genetic Absence Epilepsy Rats from Strasbourg. Neurobiol Dis. 2016 Oct;94:106-15. doi: 10.1016/j.nbd.2016.06.001. PubMed PMID: 27282256. 3. LeBlanc BW, Lii TR, Huang JJ, Chao YC, Bowary PM, Cross BS, Lee MS, Vera-Portocarrero LP, Saab CY. T-type calcium channel blocker Z944 restores cortical synchrony and thalamocortical connectivity in a rat model of neuropathic pain. Pain. 2016 Jan;157(1):255-63. doi: 10.1097/j.pain.0000000000000362. PubMed PMID: 26683108. 4. Matschke LA, Bertoune M, Roeper J, Snutch TP, Oertel WH, Rinn? S, Decher N. A concerted action of L- and T-type Ca(2+) channels regulates locus coeruleus pacemaking. Mol Cell Neurosci. 2015 Sep;68:293-302. doi: 10.1016/j.mcn.2015.08.012. PubMed PMID: 26319746.