TargetMol

TPCA-1

Product Code:
 
TAR-T3049
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3049-2mg2mg£101.00
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TAR-T3049-5mg5mg£119.00
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TAR-T3049-10mg10mg£148.00
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TAR-T3049-25mg25mg£211.00
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TAR-T3049-50mg50mg£302.00
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TAR-T3049-100mg100mg£429.00
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This product comes from: United States.
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Further Information

Bioactivity:
TPCA-1 is an effective and specific IKK-2 inhibitor (IC50: 17.9 nM); shows >22-fold selectivity over IKK-1 and >550-fold selectivity over others kinases and enzymes.
CAS:
507475-17-4
Formula:
C12H10FN3O2S
Molecular Weight:
279.29
Pathway:
Stem Cells; JAK/STAT signaling; NF-κb; Apoptosis
Purity:
0.9929
SMILES:
NC(=O)Nc1sc(cc1C(N)=O)-c1ccc(F)cc1
Target:
Apoptosis; IκB/IKK; STAT

References

1. Podolin PL, et al, J Pharmacol Exp Ther, 2005, 312(1), 373-381. 2. Du Z, et al, J Interferon Cytokine Res, 2012, 32(8), 368-377. 3. Luebke T, Schwarz L, Beer Y Y, et al. c-FLIP and CD95 signaling are essential for survival of renal cell carcinoma[J]. Cell death & disease. 2019 May 16;10(6):384.