TargetMol

PF-04418948

Product Code:
 
TAR-T3306
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3306-2mg2mg£103.00
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TAR-T3306-5mg5mg£121.00
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TAR-T3306-1mL1 mL * 10 mM (in DMSO)£125.00
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TAR-T3306-10mg10mg£143.00
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TAR-T3306-25mg25mg£228.00
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TAR-T3306-50mg50mg£343.00
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TAR-T3306-100mg100mg£371.00
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Further Information

Bioactivity:
PF-04418948 is a potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors; exhibits <30% binding at a diverse panel of GPCRs and ion channels at a concentration of 10 μM. Inhibits PGE2-induced increases in intracellular cAMP; reverses PGE2-invoked relaxation of mouse trachea (IC50 = 2.7 nM).
CAS:
1078166-57-0
Formula:
C23H20FNO5
Molecular Weight:
409.413
Pathway:
GPCR/G Protein; Immunology/Inflammation
Purity:
0.9945
SMILES:
COc1ccc2cc(OCC3(CN(C3)C(=O)c3ccc(F)cc3)C(O)=O)ccc2c1
Target:
Prostaglandin Receptor

References

1. af Forselles KJ, et al. In vitro and in vivo characterization of PF-04418948, a novel, potent and selective prostaglandin EP2 receptor antagonist. Br J Pharmacol. 2011 Dec;164(7):1847-1856 2. Birrell MA, et al. Br J Pharmacol. 2013 Jan;168(1):129-38. 3. Lu W, Yu W, He J, et al. Reprogramming immunosuppressive myeloid cells facilitates immunotherapy for colorectal cancer[J]. EMBO Molecular Medicine. 2020: e12798.