TargetMol

Rg3039

Product Code:
 
TAR-T3336
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3336-2mg2mg£96.00
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TAR-T3336-5mg5mg£111.00
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TAR-T3336-1mL1 mL * 10 mM (in DMSO)£116.00
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TAR-T3336-10mg10mg£138.00
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TAR-T3336-25mg25mg£203.00
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TAR-T3336-50mg50mg£289.00
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Quantity:
TAR-T3336-100mg100mg£422.00
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TAR-T3336-500mg500mg£862.00
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Further Information

Bioactivity:
RG3039 (PF-06687859) is a potent DcpS inhibitor. DcpS is a therapeutic target for spinal muscular atrophy. Spinal muscular atrophy (SMA) is caused by deletion or mutation of both copies of the SMN1 gene which produces an essential protein known as SMN. RG3039 improves motor function in SMA mice. RG3039 also showed activity to improve survival, function and motor unit pathologies in two SMA mouse models.
CAS:
1005504-62-0
Formula:
C21H23Cl2N5O
Molecular Weight:
432.35
Purity:
0.989
SMILES:
Nc1nc(N)c2c(OCC3CCN(Cc4c(Cl)cccc4Cl)CC3)cccc2n1

References

Rocky G. Gogliotti, et al. Hum Mol Genet. 2013 Oct 15; 22(20): 4084?4101.