TargetMol

Niraparib hydrochloride

Product Code:
 
TAR-T3353
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3353-2mg2mg£98.00
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TAR-T3353-5mg5mg£115.00
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TAR-T3353-1mL1 mL * 10 mM (in DMSO)£119.00
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TAR-T3353-10mg10mg£135.00
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TAR-T3353-25mg25mg£166.00
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TAR-T3353-50mg50mg£189.00
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TAR-T3353-100mg100mg£254.00
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This product comes from: United States.
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Further Information

Bioactivity:
Niraparib (MK-4827) is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. The PARP family of proteins detect and repair single-strand DNA breaks by the base-excision repair (BER) pathway.
CAS:
1038915-64-8
Formula:
C19H21ClN4O
Molecular Weight:
356.85
Pathway:
; Chromatin/Epigenetic; Apoptosis; DNA Damage/DNA Repair
Purity:
0.9985
SMILES:
C(N)(=O)C=1C=2C(=CN(N2)C3=CC=C(C=C3)[C@@H]4CCCNC4)C=CC1.Cl
Target:
Apoptosis; PARP

References

Jones P, et al. J Med Chem. 2009, 52(22):7170-85. Wang L, et al. Invest New Drugs. 2012, 30(6):2113-20.