TargetMol

Chelerythrine chloride

Product Code:
 
TAR-T3419
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3419-1mL1 mL * 10 mM (in DMSO)£121.00
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TAR-T3419-5mg5mg£121.00
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TAR-T3419-10mg10mg£143.00
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TAR-T3419-25mg25mg£215.00
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TAR-T3419-50mg50mg£324.00
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TAR-T3419-100mg100mg£533.00
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TAR-T3419-500mg500mg£1,083.00
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Further Information

Bioactivity:
Chelerythrine Chloride is a cell-permeable inhibitor of protein kinase C, competitive with respect to the phosphate acceptor and non-competitive with respect to ATP.
CAS:
3895-92-9
Formula:
C21H18ClNO4
Molecular Weight:
383.83
Pathway:
Cytoskeletal Signaling; Autophagy; Chromatin/Epigenetic; Apoptosis
Purity:
0.9878
SMILES:
[Cl-].COc1ccc2c(c[n+](C)c3c4cc5OCOc5cc4ccc23)c1OC
Target:
Apoptosis; BCL; PKC; Autophagy

References

P?n??kov? K, Koll?r, P, M?ller Z?valov?, V, et al. Investigation of sanguinarine and chelerythrine effects on LPS-induced inflammatory gene expression in THP-1 cell line[J]. Phytomedicine, 2012, 19(10):890-895. Chan, et al. Identification of chelerythrine as an inhibitor of BclXL function. J Biol Chem. 2003 Jun 6;278(23):20453-6. Chen XM, et al. Chelerythrine chloride induces apoptosis in renal cancer HEK-293 and SW-839 cell lines. Oncol Lett. 2016 Jun;11(6):3917-3924. Li W, et al. Effect of Chelerythrine Against Endotoxic Shock in Mice and Its Modulation of Inflammatory Mediators in Peritoneal Macrophages Through the Modulation of Mitogen-Activated Protein Kinase (MAPK) Pathway. Inflammation. 2012 Jul 24. Liang X, Cao Y, Duan Z, et al.Discovery of New Small Molecule Inhibitors of the BPTF Bromodomain.Bioorganic Chemistry.2023: 106453.