TargetMol

Lys05

Product Code:
 
TAR-T3437
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3437-1mg1mg£98.00
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TAR-T3437-2mg2mg£109.00
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TAR-T3437-5mg5mg£135.00
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TAR-T3437-1mL1 mL * 10 mM (in DMSO)£149.00
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TAR-T3437-10mg10mg£168.00
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TAR-T3437-25mg25mg£249.00
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TAR-T3437-50mg50mg£369.00
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TAR-T3437-100mg100mg£503.00
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TAR-T3437-500mg500mg£994.00
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Further Information

Bioactivity:
Lys05, or Lys01 trihydrochloride, is a potent, water soluble lysosomal autophagy inhibitor. Lys05 is a previously undescribed dimeric chloroquine which more potently accumulates in the lysosome and blocks autophagy compared with HCQ. Lys05 produced more potent antitumor activity as a single agent both in vitro and in vivo in multiple human cancer cell lines and xenograft models compared with HCQ. Lys05 is therefore a new lysosomal autophagy inhibitor that has potential to be developed further into a drug for cancer and other medical applications.
CAS:
1391426-24-6
Formula:
C23H26Cl5N5
Molecular Weight:
549.75
Pathway:
Autophagy
Purity:
0.9923
SMILES:
Cl.Cl.Cl.CN(CCNc1ccnc2cc(Cl)ccc12)CCNc1ccnc2cc(Cl)ccc12
Target:
lysosomal autophagy; Autophagy

References

McAfee Q, et al. Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency. Proc Natl Acad Sci U S A. 2012 May 22;109(21):8253-8.