TargetMol

RO 46-8443

Product Code:
 
TAR-T3474
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3474-1mg1mg£98.00
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TAR-T3474-2mg2mg£109.00
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TAR-T3474-5mg5mg£135.00
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TAR-T3474-10mg10mg£173.00
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TAR-T3474-25mg25mg£282.00
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TAR-T3474-50mg50mg£369.00
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TAR-T3474-100mg100mg£511.00
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Quantity:
TAR-T3474-500mg500mg£1,010.00
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This product comes from: United States.
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Further Information

Bioactivity:
RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition.
CAS:
175556-12-4
Formula:
C31H35N3O8S
Molecular Weight:
609.69
Pathway:
GPCR/G Protein
Purity:
0.9977
SMILES:
COc1ccc(cc1)-c1nc(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)c(Oc2ccccc2OC)c(OC[C@H](O)CO)n1
Target:
Endothelin Receptor

References

Parent R, Lavall?e M. Endothelin-dependent effects limit flow-induced dilation of conductance coronary vessels after blockade of nitric oxide formation in conscious dogs. Cardiovasc Res. 2000 Jan 14;45(2):470-7. Thorin E, Parent R, Ming Z, Lavall?e M. Contribution of endogenous endothelin to large epicardial coronary artery tone in dogs and humans. Am J Physiol. 1999 Aug;277(2 Pt 2):H524-32. Guimar?es CL, Trentin PG, Rae GA. Endothelin ET(B) receptor-mediated mechanisms involved in oleic acid-induced acute lung injury in mice. Clin Sci (Lond). 2002 Aug;103 Suppl 48:340S-344S.