TargetMol

AZD1283

Product Code:
 
TAR-T3536
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3536-1mg1mg£95.00
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TAR-T3536-2mg2mg£106.00
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TAR-T3536-5mg5mg£128.00
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TAR-T3536-1mL1 mL * 10 mM (in DMSO)£130.00
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TAR-T3536-10mg10mg£172.00
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TAR-T3536-25mg25mg£249.00
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TAR-T3536-50mg50mg£356.00
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TAR-T3536-100mg100mg£546.00
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TAR-T3536-500mg500mg£1,091.00
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Further Information

Bioactivity:
AZD1283 is an effective P2Y12 receptor antagonist (EC50: 3.0 ug/kg/min, binding IC50: 11 nM). AZD1283 dose-dependently induced increases in blood flow and inhibition of ADP-induced platelet aggregation with antithrombotic ED50 values of 3.0 and 10 μg/kg/min, respectively. The doses induced the increase in bleeding time at 33 and 100 μg/kg/min for 3- and 13-fold, respectively. Thus, the therapeutic index (TI) was ?10 for both compounds.
CAS:
919351-41-0
Formula:
C23H26N4O5S
Molecular Weight:
470.54
Pathway:
GPCR/G Protein; Neuroscience
Purity:
0.99621
SMILES:
CCOC(=O)c1cc(C#N)c(nc1C)N1CCC(CC1)C(=O)NS(=O)(=O)Cc1ccccc1
Target:
P2Y Receptor

References

Bach P,et al. Lead optimization of ethyl 6-aminonicotinate acyl sulfonamides as antagonists of the P2Y12 receptor. separation of the antithrombotic effect and bleeding for candidate drug AZD1283. J Med Chem. 2013 Sep 12;56(17):7015-24.