TargetMol

α-GalCer analog 8

Product Code:
 
TAR-T35450
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T35450-2mg2mg£950.00
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Further Information

Bioactivity:
α-Galactosylceramide analog 8 (α-GalCer analog 8) is a triazole derivative of α-galactosylceramide. [1] It increases IL-2 secretion by DN32.D3 NKT hybridoma cells when co-cultured with CD1d-transfected RBL cells pre-loaded with α-GalCer analog 8 at a concentration of 32 ng/ml. α-GalCer analog 8 (32 ng/ml) induces IL-4 secretion to a greater extent than the synthetic α-GalCer KRN 7000 in mouse splenocytes in vitro and in mouse serum following administration of a 1 µg per animal dose, indicating a Th2 response.
CAS:
922727-14-8
Formula:
C50H97N3O8
Molecular Weight:
868.3
Purity:
0.98
SMILES:
O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@]([C@H](O)[C@H](O)CCCCCCCCCCCCCC)([H])N2N=NC(CCCCCCCCCCCCCCCCCCCCCCCC)=C2

References

Lee, T., Cho, M., Ko, S.-Y., et al. Synthesis and evaluation of 1,2,3-triazole containing analogues of the immunostimulant ?-GalCer. J. Med. Chem. 50(3), 585-589 (2007).