TargetMol

Compound 401

Product Code:
 
TAR-T3586
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3586-1mg1mg£98.00
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TAR-T3586-2mg2mg£109.00
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TAR-T3586-5mg5mg£131.00
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TAR-T3586-1mL1 mL * 10 mM (in DMSO)£141.00
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TAR-T3586-10mg10mg£149.00
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TAR-T3586-25mg25mg£228.00
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TAR-T3586-50mg50mg£373.00
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TAR-T3586-100mg100mg£519.00
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TAR-T3586-500mg500mg£1,058.00
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Further Information

Bioactivity:
Compound 401 is a synthetic DNA-PK inhibitor (IC50 = 0.28 μM) that also targets mTOR but not PI3K.
CAS:
168425-64-7
Formula:
C16H15N3O2
Molecular Weight:
281.315
Pathway:
PI3K/Akt/mTOR signaling; DNA Damage/DNA Repair
Purity:
0.9976
SMILES:
O=c1cc(nc2c3ccccc3ccn12)N1CCOCC1
Target:
DNA-PK

References

Ballou LM,et al. Inhibition of mammalian target of rapamycin signaling by 2-(morpholin-1-yl)pyrimido[2,1-alpha]isoquinolin-4-one. J Biol Chem. 2007 Aug 17;282(33):24463-70. Epub 2007 Jun 11.