TargetMol

Cutamesine dihydrochloride

Product Code:
 
TAR-T3597
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3597-2mg2mg£100.00
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TAR-T3597-5mg5mg£116.00
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TAR-T3597-10mg10mg£152.00
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TAR-T3597-1mL1 mL * 10 mM (in DMSO)£164.00
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TAR-T3597-25mg25mg£259.00
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TAR-T3597-50mg50mg£432.00
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TAR-T3597-100mg100mg£603.00
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TAR-T3597-500mg500mg£1,187.00
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Further Information

Bioactivity:
Cutamesine dihydrochloride is a selective σ1 receptor agonist (IC50: 17.4 nM). It shows selectivity for σ1 over σ2 receptors, and inhibits angiotensin II-induced cardiomyocyte hypertrophy in vitro and attenuates myocardial hypertrophy in vivo. In a rat model of experimental stroke, it enhances brain plasticity and sensorimotor function.
CAS:
165377-44-6
Formula:
C23H34Cl2N2O2
Molecular Weight:
441.44
Pathway:
GPCR/G Protein
Purity:
0.99
SMILES:
Cl.Cl.COc1ccc(CCN2CCN(CCCc3ccccc3)CC2)cc1OC
Target:
Sigma receptor

References

Tuerxun T, et al. SA4503, a sigma-1 receptor agonist, prevents cultured cortical neurons from oxidative stress-induced cell death via suppression of MAPK pathway activation and glutamate receptor expression. Neurosci Lett. 2010 Jan 29;469(3):303-8. Lever JR, et al. Sigma1 and sigma2 receptor binding affinity and selectivity of SA4503 and fluoroethyl SA4503. Synapse. 2006 May;59(6):350-8.