TargetMol

A-366

Product Code:
 
TAR-T3624
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3624-1mg1mg£95.00
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Quantity:
TAR-T3624-2mg2mg£105.00
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TAR-T3624-5mg5mg£125.00
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TAR-T3624-1mL1 mL * 10 mM (in DMSO)£131.00
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TAR-T3624-10mg10mg£144.00
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Quantity:
TAR-T3624-25mg25mg£246.00
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Quantity:
TAR-T3624-50mg50mg£374.00
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Quantity:
TAR-T3624-100mg100mg£519.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
Potent and selective G9a/GLP histone lysine methyltransferase inhibitor (IC50 = 3.3 nM). Exhibits >1000-fold selectivity for G9a/GLP over 21 other methyltransferases. Decreases levels of lysine 9 dimethylation on histone H3 (H3K9Me2) in PC3 cells.
CAS:
1527503-11-2
Formula:
C19H27N3O2
Molecular Weight:
329.444
Pathway:
Chromatin/Epigenetic
Purity:
0.998
SMILES:
COc1cc2c(cc1OCCCN1CCCC1)N=C(N)C21CCC1
Target:
Epigenetic Reader Domain; Histone Methyltransferase

References

Yang D, Fan Y, Xiong M, et al.Loss of renal tubular G9a benefits acute kidney injury by lowering focal lipid accumulation via CES1.EMBO reports.2023: e56128. Zhang W, Yang D, Yuan Y, et al. Muscular G9a regulates muscle-liver-fat axis by musclin under overnutrition in female mice[J]. Diabetes. 2020 Zhang W, Yang D, Yuan Y, et al. Muscular G9a regulates muscle-liver-fat axis by musclin under overnutrition in female mice. Diabetes. 2020 Pappano WN, et al. PLoS One. 2015, 10(7):e0131716. Sweis RF, et al. ACS Med Chem Lett. 2014, 5(2):205-209.