TargetMol

CHIR-090

Product Code:
 
TAR-T3702
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3702-1mg1mg£103.00
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TAR-T3702-1mL1 mL * 10 mM (in DMSO)£148.00
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TAR-T3702-5mg5mg£148.00
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TAR-T3702-10mg10mg£197.00
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TAR-T3702-25mg25mg£338.00
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TAR-T3702-50mg50mg£499.00
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TAR-T3702-100mg100mg£691.00
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TAR-T3702-500mg500mg£1,340.00
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Further Information

Bioactivity:
CHIR-090 is a very potent and selective LpxC inhibitor with antibiotic activity.
CAS:
728865-23-4
Formula:
C24H27N3O5
Molecular Weight:
437.496
Pathway:
Microbiology/Virology
Purity:
0.9729
SMILES:
C[C@@H](O)[C@H](NC(=O)c1ccc(cc1)C#Cc1ccc(CN2CCOCC2)cc1)C(=O)NO
Target:
Antibacterial

References

Barb AW, et al. Inhibition of lipid A biosynthesis as the primary mechanism of CHIR-090 antibiotic activity in Escherichia coli. Biochemistry. 2007 Mar 27;46(12):3793-802. Barb AW, et al. Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18433-8.