TargetMol

Calycosin

Product Code:
 
TAR-T3923
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3923-2mg2mg£98.00
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TAR-T3923-1mL1 mL * 10 mM (in DMSO)£114.00
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TAR-T3923-5mg5mg£114.00
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TAR-T3923-10mg10mg£148.00
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TAR-T3923-25mg25mg£222.00
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TAR-T3923-50mg50mg£349.00
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TAR-T3923-100mg100mg£485.00
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Further Information

Bioactivity:
Calycosin acts as a selective estrogen receptor modulator. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Calycosin suppresses breast cancer cell growth via ERβ-dependent regulation of IGF-1R, p38 MAPK and PI3K/Akt pathways. Calycosin has antineoplastic effects against osteosarcoma through inducing apoptosis showing in vitro and in vivo investigations. Calycosin was shown to induce angiogenesis in human umbilical vein endothelial cell cultures (HUVEC) in vitro. Calycosin may be an effective skin-lightening agent that regulates the expression of melanogenic enzymes. Calycosin exhibited tyrosinase inhibitory activity with an IC(50) value of 38.4 microM.
CAS:
20575-57-9
Formula:
C16H12O5
Molecular Weight:
284.267
Pathway:
Proteases/Proteasome; Apoptosis
Purity:
0.9926
SMILES:
COc1ccc(cc1O)-c1coc2cc(O)ccc2c1=O
Target:
Apoptosis; Tyrosinase

References

Chen J., et al. Calycosin and genistein induce apoptosis by inactivation of HOTAIR/p-Akt signaling pathway in human breast cancer MCF-7 cells. Cell Physiol Biochem. 2015;35(2):722-8. Zhou Y., et al. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Tumour Biol. 2015 Jul;36(7):5333-9. Zhang H, Cai J, Li C, et al.Wogonin inhibits latent HIV-1 reactivation by downregulating histone crotonylation.Phytomedicine.2023: 154855.