TargetMol

Lotamilast

Product Code:
 
TAR-T3987
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3987-1mg1mg£109.00
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TAR-T3987-2mg2mg£125.00
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TAR-T3987-5mg5mg£156.00
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TAR-T3987-1mL1 mL * 10 mM (in DMSO)£158.00
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TAR-T3987-10mg10mg£201.00
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TAR-T3987-25mg25mg£309.00
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Quantity:
TAR-T3987-50mg50mg£490.00
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TAR-T3987-100mg100mg£678.00
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Quantity:
TAR-T3987-500mg500mg£1,340.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
E6005 is a phosphodiesterase 4 (PDE-4) inhibitor (IC50: 2.8 nM) potentially for the treatment of atopic dermatitis.
CAS:
947620-48-6
Formula:
C26H24N4O5
Molecular Weight:
472.501
Pathway:
Metabolism
Purity:
0.9929
SMILES:
CNc1nc(-c2cccc(NC(=O)c3ccc(cc3)C(=O)OC)c2)c2cc(OC)c(OC)cc2n1
Target:
PDE

References

Nemoto O., et al. Effect of topical phosphodiesterase 4 inhibitor E6005 on Japanese children with atopic dermatitis: Results from a randomized, vehicle-controlled exploratory trial. J Dermatol. 2016 Aug;43(8):881-7. Mano Y., Validation of a UPLC-MS/MS method for the simultaneous determination of E62005, a phosphodiesterase 4 inhibitor, and its metabolite in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Aug 15;1998-1999:31-9.