TargetMol

SMI-16a

Product Code:
 
TAR-T3989
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3989-1mg1mg£95.00
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Quantity:
TAR-T3989-2mg2mg£103.00
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TAR-T3989-5mg5mg£122.00
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TAR-T3989-1mL1 mL * 10 mM (in DMSO)£138.00
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TAR-T3989-10mg10mg£142.00
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Quantity:
TAR-T3989-25mg25mg£201.00
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Quantity:
TAR-T3989-50mg50mg£269.00
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Quantity:
TAR-T3989-100mg100mg£369.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
PIM1/2 Kinase Inhibitor VI, a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (IC50: 150/20 nM) while exhibiting little or no activity against a panel of 57 other kinases (?18% inhibition at 5 μM).
CAS:
587852-28-6
Formula:
C13H13NO3S
Molecular Weight:
263.31
Pathway:
Chromatin/Epigenetic; JAK/STAT signaling
Purity:
0.9706
SMILES:
CCCOc1ccc(C=C2/SC(=O)NC2=O)cc1
Target:
Pim

References

Hiasa M., et al. Pim-2 kinase is an important target of treatment for tumor progression and bone loss in myeloma. Leukemia. 2015 Jan;29(1):207-17. Xia Z., et al. Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases. J Med Chem. 2009 Jan 8;52(1):74-86.