TargetMol

Cucurbitacin IIA

Product Code:
 
TAR-T3S1471
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3S1471-1mg1mg£95.00
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TAR-T3S1471-5mg5mg£122.00
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TAR-T3S1471-10mg10mg£161.00
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TAR-T3S1471-25mg25mg£242.00
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TAR-T3S1471-50mg50mg£327.00
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TAR-T3S1471-100mg100mg£452.00
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TAR-T3S1471-500mg500mg£863.00
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Further Information

Bioactivity:
1. Cucurbitacin IIA can induce apoptosis and enhance autophagy , contributes to the anti-inflammatory activity of Cucurbitacin IIA against inflammation-related diseases. 2. Cucurbitacin IIA is a novel class of anti-cancer drug in suppression of cancer cell expansion by disrupting the actin cytoskeleton and directing the cell to undergo PARP-mediated apoptosis through the inhibition of survivin downstream of JAK2/STAT3.
CAS:
58546-34-2
Formula:
C32H50O8
Molecular Weight:
562.744
Pathway:
Apoptosis
Purity:
0.9862
SMILES:
CC(=O)OC(C)(C)CCC(=O)[C@](C)(O)[C@H]1[C@H](O)C[C@@]2(C)[C@@H]3CC=C4[C@@H](C[C@H](O)[C@@H](O)C4(C)C)[C@]3(C)C(=O)C[C@]12C
Target:
Apoptosis; Survivin

References

He J , Wang Y , Xu L H , et al. Cucurbitacin IIa induces caspase-3-dependent apoptosis and enhances autophagy in lipopolysaccharide-stimulated RAW 264.7 macrophages[J]. International Immunopharmacology, 2013, 16(1):27-34.