TargetMol

β,β-Dimethylacrylshikonin

Product Code:
 
TAR-T3S2344
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3S2344-1mL1 mL * 10 mM (in DMSO)£127.00
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TAR-T3S2344-20mg20mg£175.00
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Further Information

Bioactivity:
1. Dimethylacrylshikonin is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combined with IR treatment significantly suppressed tumor growth of the HCT-116 xenograft. (b) Dimethylacrylshikonin significantly suppressed the growth of H(22) transplantable hepatoma, and induced the activation of caspase-3 . (c) Dimethylacrylshikonin inhibited growth of gastric cancer SGC-791 cells by inducing ERK signaling pathway. 2. Dimethylacrylshikonin inhibits the proliferation of MCF-7 cells in vitro by inducing apoptosis through the downregulation of Bcl-2, upregulation of Bax and partial inactivation of the NF-κB pathway.
CAS:
24502-79-2
Formula:
C21H22O6
Molecular Weight:
370.401
Pathway:
MAPK
Purity:
0.9342
SMILES:
CC(C)=CC[C@@H](OC(=O)C=C(C)C)C1=CC(=O)c2c(O)ccc(O)c2C1=O
Target:
ERK

References

Kwak S , Jeong Y , Kim B , et al. ?,?-Dimethylacrylshikonin sensitizes human colon cancer cells to ionizing radiation through the upregulation of reactive oxygen species[J]. Oncology Letters, 2014.