TargetMol

QS11

Product Code:
 
TAR-T4022
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4022-1mg1mg£100.00
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TAR-T4022-2mg2mg£111.00
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TAR-T4022-5mg5mg£140.00
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TAR-T4022-1mL1 mL * 10 mM (in DMSO)£158.00
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TAR-T4022-10mg10mg£197.00
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TAR-T4022-25mg25mg£357.00
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TAR-T4022-50mg50mg£503.00
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TAR-T4022-100mg100mg£695.00
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Further Information

Bioactivity:
QS 11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation. Also reduces in vitro migration of metastatic human breast cancer cells.
CAS:
944328-88-5
Formula:
C36H33N5O2
Molecular Weight:
567.693
Pathway:
GPCR/G Protein
Purity:
0.98
SMILES:
OC[C@H](Cc1ccccc1)Nc1nc(Oc2ccc3CCCc3c2)nc2n(Cc3ccc(cc3)-c3ccccc3)cnc12
Target:
GTPase

References

Song S, Guo X, Zhang Z, et al.A universal strategy of facilitating intracellular delivery of nanomedicines based on tuning ARF6 GTPase to its GTP-bound form.Nano Today.2023, 51: 101888. Zhang Q., et al. Small-molecule synergist of the Wnt/beta-catenin signaling pathway. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7444-8. Emre N., et al. A chemical approach to stem cell biology. Curr Opin Chem Biol. 2007 Jun;11(3):252-8.