TargetMol

L48H37

Product Code:
 
TAR-T40423
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T40423-2mg2mg£102.00
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TAR-T40423-5mg5mg£122.00
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TAR-T40423-1mL1 mL * 10 mM (in DMSO)£134.00
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TAR-T40423-10mg10mg£148.00
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TAR-T40423-25mg25mg£229.00
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TAR-T40423-50mg50mg£322.00
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TAR-T40423-100mg100mg£483.00
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TAR-T40423-500mg500mg£946.00
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This product comes from: United States.
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Further Information

Bioactivity:
L48H37 is an analog of Curcumin (HY-N0005) with improved chemical stability. L48H37 is a potent and specific myeloid differentiation protein 2 (MD2) inhibitor and inhibits the interaction and signaling transduction of LPS-TLR4/MD2. L48H37 is used for the
CAS:
343307-76-6
Formula:
C27H33NO7
Molecular Weight:
483.55
Purity:
0.98
SMILES:
CCN1CC(=CC2=CC(OC)=C(OC)C(OC)=C2)C(=O)C(C1)=CC1=CC(OC)=C(OC)C(OC)=C1

References

Chen Feng, et al. Curcumin analog L48H37 induces apoptosis through ROS-mediated endoplasmic reticulum stress and STAT3 pathways in human lung cancer cells. Mol Carcinog. 2017 Jul;56(7):1765-1777. Yi Wang, et al. Curcumin Analog L48H37 Prevents Lipopolysaccharide-Induced TLR4 Signaling Pathway Activation and Sepsis via Targeting MD2. J Pharmacol Exp Ther. 2015 Jun;353(3):539-50