TargetMol

LY-294002 hydrochloride

Product Code:
 
TAR-T4079
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4079-1mg1mg£100.00
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TAR-T4079-2mg2mg£111.00
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TAR-T4079-1mL1 mL * 10 mM (in DMSO)£125.00
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TAR-T4079-5mg5mg£125.00
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TAR-T4079-10mg10mg£149.00
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TAR-T4079-25mg25mg£214.00
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TAR-T4079-50mg50mg£310.00
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TAR-T4079-100mg100mg£449.00
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This product comes from: United States.
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Further Information

Bioactivity:
LY294002 is a synthetic molecule inhibitor of PI3Kα/δ/β (IC50: 0.5/0.57/0.97 μM, in cell-free assays); more stable than Wortmannin in solution, and also is a blocker of autophagosome formation.
CAS:
934389-88-5
Formula:
C19H18ClNO3
Molecular Weight:
343.81
Pathway:
PI3K/Akt/mTOR signaling
Purity:
0.9995
SMILES:
Cl.O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCOCC1
Target:
PI3K

References

Chaussade C, et al. Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling. Biochem J. 2007 Jun 15;404(3):449-58. Gharbi SI, et al. Exploring the specificity of the PI3K family inhibitor LY2942002. Biochem J. 2007 May 15;404(1):15-21. Semba S, et al. The in vitro and in vivo effects of 2-(4-morpholinyl)-8-phenyl-chromone (LY2942002), a specific inhibitor of phosphatidylinositol 3'-kinase, in human colon cancer cells. Clin Cancer Res. 2002 Jun;8(6):1957-63. Hu L, et al. In vivo and in vitro ovarian carcinoma growth inhibition by a phosphatidylinositol 3-kinase inhibitor (LY2942002). Clin Cancer Res. 2000 Mar;6(3):880-6.