TargetMol

Thiocolchicine

Product Code:
 
TAR-T41248
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T41248-1mg1mg£98.00
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TAR-T41248-2mg2mg£109.00
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TAR-T41248-5mg5mg£135.00
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TAR-T41248-1mL1 mL * 10 mM (in DMSO)£142.00
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TAR-T41248-10mg10mg£173.00
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TAR-T41248-25mg25mg£302.00
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TAR-T41248-50mg50mg£436.00
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TAR-T41248-100mg100mg£610.00
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This product comes from: United States.
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Further Information

Bioactivity:
Thiocolchicine is an effective inhibitor of tubulin polymerization with an IC50 of 2.5 ?M and a Ki of 0.7 ?M. Thiocolchicine induces cell apoptosis. Thiocolchicine can be used as an ADC cytotoxin in ADC technology.
CAS:
2730-71-4
Formula:
C22H25NO5S
Molecular Weight:
415.5
Pathway:
Cytoskeletal Signaling
Purity:
0.98
SMILES:
COc1cc2CC[C@H](NC(C)=O)c3cc(=O)c(SC)ccc3-c2c(OC)c1OC
Target:
Microtubule Associated

References

Klaus M.Hahn, et al. Structural requirements for the binding of colchicine analogs to tubulin: the role of the C-10 substituent. Bioorganic & Medicinal Chemistry Letters.Volume 1, Issue 9, 1991, Pages 471-476 R De Vincenzo, et al. Antiproliferative Activity of Colchicine Analogues on MDR-positive and MDR-negative Human Cancer Cell Lines. Anticancer Drug Des. 1998 Jan;13(1):19-33.